Weight Gain with Atypical Antipsychotics – A Review of Strategies

Peter Forster Bipolar Treatment, Physical Conditions and Health

Many antipsychotics, especially some atypical or second generation antipsychotics, like olanzapine (Zyprexa) or quetiapine (Seroquel), cause significant weight gain, as well as insulin resistance (diabetes) and elevated lipids. What to do if the medication is helping (much more than alternatives) but the patient is developing these serious adverse effects? Two recent articles review the literature on strategies for managing these …

Genetic Testing Guides Treatment for Bipolar or Depression

Peter Forster Diagnosis, Testing

We have been using a relatively new assay from a company called Genomind (the Genecept test) in some of our patients with bipolar and/or depression. The test involves a saliva sample which is analyzed for ten gene variants that may be useful in guiding treatment. So far we find that in about half of the patients with treatment resistant depression …

Lithium versus Quetiapine for Bipolar Disorder

admin Uncategorized

In a recent study comparing the efficacy of lithium and the second-generation antipsychotic quetiapine, the drugs had remarkably similar results. Researcher Andrew Nierenberg et al. presented the results at the 2014 meeting of the American Society of Clinical Psychopharmacology.┬áBy the end of the 6-month study period, most patients had improved substantially, but only about a quarter of each group became …